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PH2.6-8 | Autacoids and Pain Pharmacology — Assignment
Grading Rubric — Autacoids and Pain Pharmacology — Assignment Rubric
| Criterion | Points | Full-marks descriptor |
|---|---|---|
| Antihistamine Pharmacology (PH2.6): Explains correct generation selection, mechanism, side-effect profile, and dose adjustment in CKD | 4 pts | Exceeds: Correctly identifies second-generation antihistamine with specific mechanistic justification (BBB penetration, muscarinic selectivity), provides exact dose adjustment for CKD, and addresses patient counselling |
| NSAID/Analgesic Pharmacology (PH2.7): Identifies COX selectivity, contraindications in CKD, triple whammy interaction, safest analgesic choice | 5 pts | Exceeds: Correctly identifies triple whammy mechanism; names paracetamol as safest analgesic with mechanistic justification; addresses NSAID renal toxicity in CKD; identifies triptan contraindications requiring cardiac workup |
| Gout Management Plan (PH2.8): Correct acute treatment selection respecting contraindications; timing of allopurinol; monitoring | 6 pts | Exceeds: Selects appropriate acute gout drug (NSAID or colchicine with dose) given CKD eGFR 62; correctly defers allopurinol to post-attack resolution (≥2 weeks); explains aspirin-uric acid interaction if applicable; specifies monitoring (uric acid, creatinine) |
| Integrated Prescription and Patient Safety: Complete, internally consistent prescription with monitoring plan and patient counselling | 5 pts | Exceeds: All drugs correctly named with doses; drug list internally consistent (no contraindicated combinations); monitoring parameters specified; patient counselling includes drug–food interaction (antihistamine + fruit juice), OTC NSAID warning, and triptan cardiac check |