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PH6.1-5 | Gastrointestinal Pharmacology — Assignment

Grading Rubric — Gastrointestinal Pharmacology — Case Study Rubric

Criterion	Points	Full-marks descriptor
Pathophysiology (PH6.1) — identifies dual mechanism (H. pylori + NSAID) with pharmacological precision	4 pts	Exceeds: Explains both H. pylori virulence factors (urease, VacA) AND NSAID COX-1/prostaglandin mechanism; notes reversibility difference between the two; integrates defensive/aggressive factor framework
Management plan (PH6.1, PH6.2) — prescribes complete, correct H. pylori eradication regimen with pharmacological justification	6 pts	Exceeds: Prescribes correct OAC regimen (omeprazole + amoxicillin + clarithromycin × 14 days) with dose/route/frequency; explains WHY PPI is pharmacodynamically essential for antibiotic efficacy; correctly advises NSAID discontinuation + gastroprotection if NSAID continued; does NOT prescribe ranitidine
Prokinetic choice and rationale (PH6.2) — selects appropriate agent with mechanism and adverse effect awareness	4 pts	Exceeds: Selects domperidone over metoclopramide for outpatient use; explains peripheral D₂ antagonism vs central D₂ risk (tardive dyskinesia); or selects metoclopramide with explicit acknowledgement of extrapyramidal risk and short-course plan
Follow-up and safety (PH6.1, PH6.3, PH6.5) — demonstrates clinical safety thinking including eradication confirmation and prescribing error identification	6 pts	Exceeds: Names urea breath test/stool antigen at ≥4 weeks post-antibiotics for eradication confirmation; states repeat endoscopy for gastric (not duodenal) ulcers at 6–8 weeks; identifies the loperamide-in-dysentery error OR the ranitidine-withdrawal error as the high-stakes prescribing risk with mechanism